Anti-Cardiolipin Antibody (ACA) ELISA Kit

Short Description:

Antiphospholipid syndrome (APS) is a syndrome characterized by recurrent vascular embolism, miscarriage or intrauterine fetal death, thrombocytopenia, and neuropsychiatric symptoms, accompanied by persistent positivity for lupus anticoagulant and/or medium to high titers of anticardiolipin antibodies (ACA). Since medium to high titers of ACA are present in APS patients and persist over time, ACA serves as an important basis for diagnosing APS.

ACA is a group of heterogeneous antibodies with IgA, IgG, or IgM subtypes, among which IgG and IgM are the most common. Marai et al. tested 66 patients with primary APS and 60 patients with secondary APS, and found that the positive rate of ACA IgG was 25% to 33.3% and that of IgM was 1.6% to 7.5%; IgA antibodies were not detected separately. The positive rate of IgG-type ACA is the highest in patients with cerebral thrombosis, and it is closely associated with clinical manifestations. IgM-type ACA can serve as a prospective indicator for spontaneous abortion or stillbirth. Thrombocytopenia is more common in patients with IgG-type ACA and correlates with the severity of thrombocytopenia. Hemolytic anemia and neutropenia are associated with the IgM type.